diff --git a/.github/workflows/ci-build.yml b/.github/workflows/ci-build.yml
index 8c3618c..9863044 100644
--- a/.github/workflows/ci-build.yml
+++ b/.github/workflows/ci-build.yml
@@ -28,7 +28,7 @@ jobs:
 
     strategy:
       matrix:
-        python-version: ['3.7', '3.8', '3.9']
+        python-version: ['3.7', '3.8', '3.9', '3.10']
 
     name: Build with Python ${{ matrix.python-version }}
     steps:
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 62fb509..2ec7c7e 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -1,6 +1,7 @@
 ## 4.0.0 (unreleased)
 
 - Drop support for Python 2.7, 3.5 and 3.6
+- Add support for Python 3.10
 - Drop support for Django 1.11, 2.0, 2.1, 3.0
 - Fix index creation detection when table is being created in the transaction (issue #178)
 
diff --git a/setup.py b/setup.py
index 774318c..0d1914e 100644
--- a/setup.py
+++ b/setup.py
@@ -59,5 +59,6 @@ setup(
         "Programming Language :: Python :: 3.7",
         "Programming Language :: Python :: 3.8",
         "Programming Language :: Python :: 3.9",
+        "Programming Language :: Python :: 3.10",
     ],
 )
diff --git a/tox.ini b/tox.ini
index 9dc51fa..177db2b 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,7 +1,7 @@
 [tox]
 envlist =
     py{37,38,39}-django22
-    py{37,38,39}-django{31,32}
+    py{37,38,39,310}-django{31,32}
     lint
     coverage
 
@@ -10,6 +10,7 @@ python =
     3.7: py37
     3.8: py38
     3.9: py39
+    3.10: py310
 
 [testenv]
 commands = ./manage.py test --no-input {posargs}